Climbazole（CAS38083-17-9）

Alias name

1-(4-Chloro-phenoxy)-1-(2,5-dihydro-imidazole-1-yl)-3,3-dimethyl-butan-2-one;1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimetChemicalbookhylbutanone;BAYMEB-6401;Diadimefon;MEB-6401;Climbazole0.1;1-[(4-Chlorophenoxy)(tert-butylcarbonyl)Methyl]iMidazole;CrinipanAD

CAS

38083-17-9

EINECS

253-775-4

Molecular formula

C15H17ClN2O2

Molecular weight

292.76

Chemical formula

Density

1.17±0.1 g/cm3(Predicted)

Melting point

96-100°C

Boiling point

447.5±40.0 °C(Predicted)

Flashing point

224.4°C

Water solubility

58mg/L at 25℃ Soluble in toluene    and alcohol, insoluble in water

InChI

InChI=1/C15H17ClN2O2/c1-15(2,3)13(19)14(18-9-8-17-10-18)20-12-6-4-11(16)5-7-12/h4-10,14H,1-3H3

InChIKey

OWEGWHBOCFMBLP-UHFFFAOYSA-N

Refractive index

1.54

Acidity coefficient

5.66±0.22(Predicted)

Storage condition

Inert atmosphere, room temperature

Appearance

White to almost white

Colour

White or off-white crystals or crystalline powders

BRN

618020

MDL

MFCD00055505

LogP

3.83 at 25℃

Vapour pressure

0.001Pa at 25℃

HS

2933290012

Use

With broad spectrum bactericidal performance, it is mainly    used for anti-itch, anti-dandruff conditioning shampoo and hair care shampoo,    and can also be used for antibacterial soap, shower gel, drug toothpaste,    cough liquid, etc

Package

25KG/40KG Packing bag,    cardboard bucket

Dangerous mark

Xi-Irritating substance           
     N -Articles harmful to the environment

Risk phrases

R22 - Harmful if swallowed
     R50/53- It    is highly toxic to aquatic organisms and may have long-term adverse effects    on the water environment

Safety phrases

S60-The substance and its container shall be disposed of as    hazardous waste
     S61 - Avoid release into the environment. Refer to the special    instructions/Safety Data sheet.

Dangerous goods transport No.

UN 3077

WGK Germany

3

RTECS

EL7085000

Upstream raw materials

Pyrazole imidazole

Down-stream product

Methidathion

In vitro study

Climbazole has shown high anti-pityrosporum ovale efficacy in    vitro and in vivo, which may be the main cause of dandruff production. The    chemical structure and properties of Climbazole are similar to those of other    antifungal agents, such as ketoconazole and miconazole. The MICs of    climbazole ranged from <0.06 to 1 μg/mL, with a median experimental value    of 0.06μg/mL

In vivo study

Climbazole    was not mutagenic in Salmonella typhimurium or Escherichia coliAmes assays    and did not induce micronuclei in human lymphocytes. An in vivo mouse    micronucleus test also showed that it was not mutagenic, and the maximum    tolerated dose (MTD) for oral administration was up to 150 mg/kg. In    unconventional DNA synthesis assays in vitro and in vivo, climbazole showed    no DNA damage in rat liver at MTD up to 200 mg/kg administered orally. In    mice